Orange oil is listed as GRAS by FDA as an essential oil and natural extractive at 21CFR 182.20.
d-Limonene is listed as GRAS by FDA as a synthetic flavoring substance and adjuvant at 21CFR 182.60.
The Food Chemicals Codex (FCC) provides the accepted standards for quality and purity in food chemicals and is officially referenced by the FDA and many agencies in other countries. The monographs for citrus oils provide a physical description of the substance and its use in foods, lists their purity requirements, describes the appropriate tests to determine compliance, and provides packaging and storage guidelines. Also, where feasible, FCC specifications are now harmonized with those of other standard setters, in particular the FAO/WHO Compendium of Food Additive Specifications.
Citrus oils are not listed as Hazardous Air Pollutants (HAP) by the U.S. EPA.
Citrus oils are not listed as endocrine disruptors by the U.S. EPA.
Citrus oils not are listed in the National Toxicology Program’s (NTP) report on carcinogens by the U.S. Department of Health and Human Services.
Citrus oils are not listed as carcinogens by the International Agency for Research on Cancer (IARC).
Citrus oils are not regulated as ozone depleting compound by the Montreal Protocol.
Citrus oils are not listed as Toxic Air Contaminants (TAC) by the California Air Resources Board.